The 150 grain weight is good out of a 308. A 165 would also be good for long range shooting and may give a little better penetration. Especially with the Nosler Ballistic Tips, the 165 could be a better choice because it would be more likely to exit and give you a good blood trail. I had the same problem with a nonexistent blood trail a couple years ago when I shot a mule deer at 320 yards with my 270 and 130 grain Power Points (which is similar to the Ballistic Tips on that it opens up very quickly.) The bullet hit perfectly, just behind the shoulder, but did not exit, and luckily the buck only went 30 to 40 yards straight down the hill and went down. But, I could not find one drop of blood anywhere, not even where the buck was laying. So I'm really of the opinion now that if you want a blood trail, you need an exit wound. The Nosler Partitions another poster mentioned will get the job done, and so will the Barnes Triple Shock. With the Barnes, definitely stay with the 150 instead of the 165.