Although I cannot comment on the original question regarding sighting in the different gr PB I must agree with Swampthing and Catus Magnus regarding penetration and performance of the 245 PB. My friend swears by them because he can dump 90 gr of RS in his black diamond and buy a package of powerbelts and he's ready to roll. He's been fortunate that he's a good shot because any bullet would have killed his deer. Two deer we butchered last year and one so far this fall have been hit broadside in the vitals without any pass through. These shot are all under 50 yards. The bullet disintegrates completely leaving bits of lead all over the place. He's under the impression that this is optimal performance (schrapnel & soft tissue injury), however, as I think most of us would agree two holes to bleed through are better than one- and to accomplish this you need the projectile to hold together.

I don't use them mostly because I'm cheap and perfer sabots.

Tom