It really depends on your hunting situation. Since you are in NY, you may well not have too many shots beyond 100-150 yards. Hence, I would zero my rifles at the range you expect to shoot your game and be done with it!

Now, if you are going out west, where you may have to stretch that 300 out past 300, I'd put it 2" high at 100, and hold dead on out to 300 yards. Simple is mo' better, so to speak.