Guys, I know this is the right forum for this but I know people hear generally know there stuff and I won't get as much media-tainted jargon.

I'm looking at getting a deer-dual/purpose rifle this summer. I cannot decide on a caliber. Coyotes, and deer are the game and shots may go as long as 300. I've looked at 30-06, 243, 308, 7mm-08, 25-06 and maybe a few others. I can't decide. I will handload. I'm beginning to be a fan of the small-fast crowd but come from the big-slow camp. This year I'm at school and all I have is a 22-250 since I come from a shotgun-only state. Took a doe yesterday at 40yards with it and some 64gr powerpoint. Dropped her in her tracks on a front chest shot. Needless to say I was pleased, and honestly, surprised. What calibers do you guys have experience with, in a commercially available gun, that finds that sweet spot between flat-recoil-and humane, quick kills?