My longest shot was ranged at 387 yards. Dropped like a wet card table.
You don't like doing it, but with the right gun, lots of practice, knowledge of balistics, confidence, and a certain amount of luck, the shot is possible.
Bowhunting was the closest at 47 yards.
With antelope, you take the shot they give you, or they are gone over the first rise and there is not chasing them!