Gosh, I have a 270, 308, 7mm-08, 300win mag, 300RUM, 7mmSTW, 45-70, 2 slug guns, 2 muzzleloaders. Can't say the deer I shot with the 270 showed any differnce in dropping with any of em. The 45-70 however when hit in the shoulders will pick them up and throw them down with authority.