i'll second the motion of the 280 Rem (7mm Rem Express) as an all around versitile cartridge... 100 gr hornady HP's for coyote and woodchuck... or 175 Partitions for deer, bear, elk, moose, and so on and so forth... and a whole mess of weights, types and manufacturers in between....

my 280 is a rebarrelled 700 Mountain Rifle... i handload everything and i don't push the envelope i go for precision and accuracy... my 175 partitions leave home at about 2690 FPS and go to the same place time after time... 7828 and H4831SC are great powders for heavy weight bullets...

btw, don't let anyone tell you that a core-lokt won't do it's job... i am quite sure that many are used every year to kill a whoooooooole lotta critters... quickly...