I am fine with small bore like the .30 until bear & bison get in the picture. Then I would let size of the beast be my encouragement for a larger wound channel. I am quite sure that if bison & grizzly had their old range and numbers back, you would see a much bigger market for larger calibers! I know some like the 7mm Rem Mag for pretty much everything. And it has some really good bullets. Not my choice tho.