Dan, I have done a little tinkering with the 375 H&H.
I have pretty much settled on 2 loads, one with a 260 Nosler AB with Reloader 15 and the other comprising of a 270 gr Barnes TSX and IMR-4350. In my Sako M75 both loads shoot great, though I only shoot 3 shot groups with it, sub MOA groups are common. I use Winchester brass and Wimchester WLR magnum primers. I use a light crimp in the Nosler's cannelure and in the X bullet it's second groove.
These are loads with the 270 gr Barnse TSX and IMR-4350 powder