For factory loads, when I find a good one, I stay with it. I quess I should with handloads too but I usually end up trying many different bullets.

I am however getting tired of that game and am going to start treating hand loads the same way. I will load the Noslet Partitions or Barnes TSX in everything that will shoot them well. For deer and antelope I may still use some Hornady Interlocks as well.