RE: My gun for Africa....
CZ makes a good and reasonable big bore. I believe it can be had in 375 H and H and 416, possibly in 458 win as well. 375 is the classic african caliber. Makes a good elk rifle too. Most but not all african hunters consider the 375 a great all around african rifle. May elephants have been taken with this caliber. But some consider it marginal for elephant. The 416 lott is probably the best all around african caliber. But if you are not going for elephant the 375 would be great