With a gun, I like the scapula (similar to a high shoulder) shot. There was an excellent article in Deer & Deer Hunting last fall, which talked about the shot. Of course, this shot only works well with a gun. If you hit a deer where the white dot is shown in the picture linked below, it won't go ANYWHERE. A slight miss high hits the spine, and a low shot hits the top of the vitals. I made a shot like this on the last deer I killed with a rifle and he dropped like a sack of mud.