Due to their low sectional density, I consider any .45 cal. bullet under 200 grains to be unsuitable for deer or anything larger. In my fast-twist .45's, for deer I am now shooting the Lyman .457122HP, 330-grain Gould cast pure lead bullet UNLUBRICATED and100 grains of FFFg or Pyrodex P, with a Wonder Wad on top of the powder charge. The Wonder Wad provides the lubrication. I size the bullets .002 under land diameter for a sliding fit, similar to a Power Belt, but WITHOUT the Power Belt plastic wad that MUST FALL OFF QUICKLY TO GIVE YOU ACCURACY. I have found that since CVA started marketing Power Belts, the plastic wads don't come off reliably any more, (they used to!) and this accounts for their mediocre accuracy these days.

The .457122HP is a great deer bullet, but too light and too quick-opening for elk or moose. For these I use a Lyman 400-grain solid cast plain-base flatnose bullet, also sized for a tight sliding fit in the bore. Both of these bullets duplicate .45/70 performance with proper powder charges. This is plenty of power for North American game - you don't need a .50, unless the law requires one.....