It really depends what I'm shooting. If I'm loading up for my 20BR, I'm starting with Lapua brass. The flash holes are drilled and the primer pockets are already very uniform, so after the cases have been run through a series of forming dies and an ironing die, I just trim to uniform length, chamfer, load and shoot. For my 300WinMag, I full length resize the new brass, trim to uniform length and chamfer, uniform primer pockets, deburr flash holes, sort into weight groups, and load. For my 7-08AI, I use Winchester .308 brass necked down to .284 a little at a time until I get a crush fit (cases tend to last longer than starting with 7-08 brass), deburr flash holes, uniform primer pockets, trim to uniform length and chamfer, neck turn just enough to remove the high spots, and sort in weight groups, and load. While a deer shot with a cartridge with a case prepped this way will not be any more dead, I believe that my custom rifles deserve custom ammo. I've spent too much on the rifles to not be particular with my handloads. Besides, I enjoy reloading.

You really don't have to be as anal as I am when reloading, but it is generally a good idea to deburr the flash holes. Sometimes there is a genuine brass trap door interfering with primer ignition. Deburring flash holes needs to be done only once, and it tends to eliminate that occasional unexplained "flier."