It is generally accepted that anything past 30 to 40 yards is not reponsible. Thirty is the accepted norm. I love the animals I shoot and would not shoot at any deer that is calm beyond 40 yards and beyond 30 if it acts "twitchy or nervous". Some guys will not shoot beyond 30 regardless. The range is no different from a fast compound bow. Do yourself a favour and check out how long it takes for a crossbow arrow to reach 50 yards. Then ask yourself if something could happen during that period. Then ask yourself if you think it is fair to take that risk on an animal. Then ask yourself if it is humane to take a risk. Then ask yourself if it is responsible to take a shot at a sure thing. These are the questions I ask myself on every single shot. No judgement made on anyone here just a reality check.