Only you know what kind of marksman you really are. If you are capable, a .22lr between the eyes or behind the ears is lethal yote medicine. This I know. I've never used 00buck, but assuming it patterns well enough I wouldn't doubt its abilities either. Did some quick research...00buck are .33" and about 50grains each, so compare that to your .22 that moves faster and it looks like a toss up (on paper at least). I guess take just take your pick.