I sight in on 3x @ 50 yards, then 6-12x @ 100 yards and farther. Once I am hitting well, I will turn down the power and shoot at 100 and 200 yards. I will try on 4x at 100 yards and around 6 power for 200 yards. Just a personal thing to see if still fairly accurate at a lower power shooting a longer distance, as you never know when a longer shot needs to be attempted in a short time and at a lower power setting. I believe and others I have read have stated, that all scopes with shift POI, as least a little bit when changing power setting.