These are my thoughts on this subject. My Horton Yukon SL only shoots at around 260 fps and I think my longest shot on any of my deer taken (13) has been 25 yrds. To date, I"ve not had a single one of them "jump the string". Could be luck, but I don't think so!
You are talking about a CB that shoots 20fps faster than mine. I don't think you should have to worry about aiming a bit low to compensate for a deer"loading up" to avoid being hit and breaking camp on you. Like what was said earlier, aim where you want your bolt to impact, within reason!Like I've said before, by the time a deer hears that release it's already dead on its feet.
Again, these are only MY thoughts on this subject.