There are advantages and disadvantages to all of them. Cost wise, around here, Pyrodex RS pellets are the cheapest. While they fowl the barrel more then American Pioneer Sticks or Triple Se7en, the fowling is still soft and easy to swab. Triple Se7en on the other hand, shooters can still experience the hard crud ring which forces them to swab between shots, they cost more, and are technically no more powerful then RS or APP. APP pellets from all reports seem to work good, but I have never shot them. I've heard from other posters that while accuracy is good with them, they are not happy with the "condition" of the sticks sometimes. They report chunks missing from the sticks. That would be a turn off for me right there. I am currently shooting APP 3f loose, and not real impressed with it, especially after todays shooting session.

All rifles have to be cleaned at the end of the day. While Pyrodex RS might take a few minutes more to clean, if your rifle is sighted in with that now, and you are happy with the accuracy, my question to you is, why change powders? Granted it is fun to experiment, but the other powders are no guarantee of better accuracy.