I find the 165gr Nosler Partition to be thebest all aroundchoice in my 300WSMfor small, medium and larger game. It's the perfect combination of speed and weight. For powder I have excellent results with Ramshot Hunter. Hunter gets my 165gr Partitions moving around 3150fps with sub MOA groups. Other powders that work well in the 300WSM are any of the three 4350s, IMR4831, H414, R-19, R-22 and MagPro. Only your rifle will know for sure what is the best powder and bullet combo.