I cut my teeth hunting deer here in central Alabama, in front of dogs. I first tried a 12 ga and buckshot, but after seeing a few deer get away wounded, I switched to a 270. I didn't allways get my deer with the first shot, but I got my deer. If you are absolutely certain a twig didn't deflect your bullet, and you are certain your bullet preformed as expected, and you are certain you didn't flub up your shot ,then don't shoot again. But most of the time nobody is that certain!I've had some dead eye dicks come here to sight in their super magnums and flinch so bad they couldn't hit paper at 100 yds, and most of them were one shot wonders, just didn't eat much venision. I think if the chance is offered take a second shot or a third cause if it gets over the hill someone else will likely claim it anyhow.