Are you talking about rifle, or caliber?

If it's the former, go wherever you can fondle the most guns simultaneously, & go with the one that fits you best, and/or the one that's "neatest" to you: bolt, pump, lever, semi-auto, etc. Then see what calibers it's offered in.

Ifyou're seeking opinions on caliber, pick anything from a .243 on up, & it'll kill deer fine. (I'm kind of looking at picking up something in a .260 or 7mm-08, myself: negligable recoil, & pokes a bit wider hole than a .243.)

By the way, get ready to get tons of responses to this!