FVA, I stated I have seen poor results from a 243 in my neck of the woods. Were I live (Sask, Canada) and hunt it is rare a whitetail buck goes under 200 and if you shoot a mature buck even in the prime of rut very rare to have one that won't take 250 on the hoof.

You can take them down with a 22 if you hit them just right, but personally I would never use a 243. Seen it and don't like it...JMO.