I am a lefty and grew up shooting righty firearms all my life too. But here's a weird example of what I recently did.... I went back to the original way with righty firearms and shooting them lefty.

See, I had a lefty version of a Remington 870 12GA. It was a great shotgun and all. The cross bolt safety was lefty too. It was a sweet gun. But then, it would confuse me or I'd get confused when handling my other firearms because of the safety (on my old Marlin model 60 .22LR from my childhood days and my Marlin 30AS 30-30 rifle). Then I went to look at accessories for the lefty version 870 and realized I can't get squat for it because it's "lefty" and apparantly the (if any) accessories have to be custom made. Long story short, I went up to the gun shop a few weeks ago and simple swapped it out and got a totally brand new Remington 870 12GA in normal right format, then just paid a few $$ in the difference between the two.

The only thing that is solid lefty is my Reflex Highlander. I am left eye dominant and shoot lefty (there ain't no way around that with a compound bow!). Everything else is righty and works fine for me and has for decades. I don't own a bolt action rifle but have shot them before lefty, and didn't have any problems.

As far as semi-autos (marlin model 60 .22LR among others), I grew up learning to hold my right arm and elbow down a bit, so the ejecting shell passes over my arm and doesn't biff me. My dad taught me to do that when I was a kid. I qualified on the M-16 in bootcamp all those years ago, shooting lefty too.

I guess being a lefty in a righty dominant world, you just learn to adapt....