i think it really depends on you..how accurate are you at 25 yards? how confident are you in making a shot and also how open is the terrian? if you are a good shot and highly confident (not to say we are not humans and can make a mistake) and the area is open for say atleast 100-200 yards of area where you can watch the bull i would shot it at the neck...there are too many large veins, back bone, jugular etc. that you can hit and it be a good kill shot....also i would only do if i had a broadhead with atleat 1 3/16 cutting diameter..anything less no way..