A lot depends not only on bullet weight, but bullet ballistic co-efficient. I'd rather have a pointed 250gr bullet than a flat nosed 444gr bullet if I were shooting 100+yds, as they don't drop as quickly(noticing they're more aerodynamic);and because they keep their speed up, they have the advantageon thefarther the shots, and the advantage only gets better the farther the shot. For example, a 165gr spire point bullet in a 30-06 or a 220gr. round nose bullet. Which would you want to shoot farther off? The 165 has a better BC, so even if they started off at the same speed, the 165 has less trouble piercing through air so it will shoot flatter and the energy advantage will shine in far distances. Being said, you aren't going to shoot a 220gr nearly as fast as a 165gr anyways.