It really depends on the gun you are shooting it out of. Out of my 5lb beast of a pistol 460 XVR Performance Center with 10.5" barrel and scope, a 300gr 454 load is quite a ***** cat. Out of a ruger, it can be a handful.
Full tilt 200gr 460 loads out of this pistol kick like a 24gr H110 240gr XTP 44mag load in my Model 29 smith. All depends on the pistol.