I'm using 150gr Remington Corelokts in my 300WM. I'm using it on small southern whitetails out to 250yrds. I only got to shoot 1 deer with it last year, but 1 shot to the neck at 225yrds and it was lights out for her. The exit wound was bigger than my fist, so even if she had been able to run, I'm sure there would have been a pretty good blood trail to follow.