For big game the 140gr Woodleigh is great and the 120gr Nosler will handle anything else, I find that the 120gr is where the 260rem shines.
Out of my little 20" model 7 barrel I load 100gr pills up to 3300fps and the 120gr's to 3000fps, I get the 140gr pills out at 2800fps but the funny thing about any 264cal is that they kill out of all proportion to their paper balistics. I dont often have to put a second shot into anything with my 260 as it has this amazing ability to drop things on the spot.