Another Savage shooter here. Most likely I will be shooting 45 grians of 5744, a 250gr XTP, MMP HPH-12 sabots, and Win. 209 primer.
Skeeter, give 42-43.5 grains of VV N-110 a try with thoase 250gr SSTs. I think you'll like the results.
Like Duffy says:
NEVER USE SMOKLESS POWDER IN A MUZZLELOADER (unless it is one like the Savage, mentioned by Sheeter,that is oked by the manufacturer).