Topcow,
For the 22-250 the powders I use are IMR4895, IMR4064, and going to try VVN140. For the 270 I use Reloader19, and IMR4350. I like the IMR4895 with 40gr bullets, seems to give the best accuracy. I like the 40gr Sierra Blitzkings, and Nosler 40gr. Ballistic tips.

Rem. 222