WOW, I never really thought of any reason what so ever one would want to do that if buying a new bow...if your buying one, buy a proper one...string slap should never be a problem with proper bow length and form....

Shooting one opposite handed could of course be consistance when redundancy/repetitiveness is acheived however down sides could be not having enough adjustment in sights, rests adjustments, odd form etc...I'd imagine one could do it, I just don't know why one would.