unless you reload, i would base my decision on ammo availability (keep in mind the .221 has been discotinued once and does not have a big following and may not last)The 22-250 is a good round but may be overkill for what you are hunting unless x-treme range is your desire.The .223 is a lot more quiet, cheaper and very deadly out 300-350 yds or more if you're good. Whatever you choose,enjoy-be safe-have fun!

If I ain't huntin',I'm trappin',If I ain't trappin',I'm fishin'
If I ain't fishin',I'm wishin'!