... I don't even put these two rounds in the same class... it would be like saying what's best for deer, the 30-30 or the 30-06... just two different classes of cartridge. Both have their place, but are radically different in their application... in my opinion.
The 22-250 is a great varmint cartridge...but it's LOUD.... you MUST wear ear protection when shooting it.. the 221 out of a rifle is basically a 222 Remington... milder, and not as good at extended ranges... but MUCH easier on your ears, and your barrel.

"Progress, far from consisting in change, depends on retentiveness..those who cannot remember the past are condemned to repeat it." Santayana