I can't agree with EKM. Its just not my nature. However its pretty hard to argue with his logic this time. I have bunched my calibers up a few times just trying to try everything. However I would have to have the .22 RF ,223, 12 Ga BPS and a 30-06 or 308 or 270. The 30-06 would offer themost versitility of my upper three. Most calibers I have tried just to see how they compared to others. For my hunting anymore, I would add the 45-70 to the top. If younger, the 375 H&H or my old favorite, the 416 Rem Mag. The latter is maybe a bit less versitile but a real thumper.