A mature doe is a worthy adversary! In my home area it is difficult to come to a conclusion because of the herd balance being so out of whack.There are so many more doe's than bucks that the sheer numbers have the doe's being so much more likely to be killed.
I definitely believe that a 41/2 year old buck or older is the most astute and aware deer that exists.It will respond to pressure immediately and is the most cautious and amped up deer there is.
I do believe though that doe's will become increasingly more difficult to kill as the season progresses and they are subjected to more and more pressure.I have seen doe groups become almost nocturnal and secluding themselves in the thickest cover they can find.
Last night I was glassinfg a field that had several deer in it.I was on a tree line with pretty good cover,the biggest bodied doe in the field saw me at over 200 yards away and stared at me for several minutes before she would go back to feeding.There were several younger doe's in the feild who never saw me and a 21/2 year old eight pointer who never saw me.She was so much more aware then these other deer.