I don't know that I would perosnally try it, but yes they will. That is what they made the 20 grn XTP rounds for, better penitration on larger game. Asl long as you keep the range in mind and have proper shot placement the 17 will work in my opinion.

I don't even own a centerfire, but if I were to go coyote hunting I think I would take my slug gun or Inline Muzzle loader before my 17, but that's just me. I figure the effective ranges are about the same but the larger guns carry waaaaay more energy at the target.

Paul