Barnes, failsafes, etc, have a solid shank. They build pressure much faster than other bullets. Lets say you shoot 96gr of H1000 with 180gr sierra in a RUM. No pressure signs and seems safe. Try that with a 180gr TBBC, and you might blow the gun up and best case, you just locked the brass up in teh chamber. Scirrocos have a very soft very thick jacket that also builds up pressure faster than most.

You need to load with what you want to hunt with. Every bullet/load combo is different. I can get 53gr of IMR4350 and 130gr gamekings to shoot great in my 270win, but switching to 130gr bullistic tips, I need to drop it to 51gr. In fact, I had to change powders to 4064 to get it to shoot accurately.

Here is what I do. With a caliber, I have a particular bullet in mind I desire to shoot. For example, I picked up a 300win mag a few weeks ago. I want this gun to shoot 180gr accubonds. First choice. So I look at all teh data and what powder I have on hand, and decide RL22 is an appropiate first choice. I try it, if it doesn't work, I will try 4350, if that don't work, I will change over to 165gr to see what it does. Have a bullet in mind you want to work for you.