I always get a laugh out of these posts...And wonder how many that answer that it won't have tried???

Recently we had this asked at another hunting forum...Many said..Why???
Turns out the guys nephew had cancer...couldn't shoot anything bigger...

I have killed many with a 22-250....back in the '70s for population control...Back then, nobody had a "deer rifle"...They had been wiped out of NC years ago...This was way before we had bullets for a .22 caliber designed for deer...My niece killed two does last year on the same hunt. within 30 minutes of each other...Both dropped on the spot...Killed with a 22-250 and Federal Premium 60gr Nosler Partition...I cleaned both of them...Both were shot through the shoulder blade and had a hole on the offside an inch wide...Just as dead as if killed with a .270.
There are several local guys that like to target shoot, groundhog hunt etc. They have .223s, 22-250 and 220 Swifts....All handload, they can hit a dime at 100 yards...And kill deer...2-3 a year for the freezer...They aren't what we would consider "deer" hunters...They are more target shooters that might own 50-60 acres and kill a deer on the backside of their property...They can pick and choose their target...Don't have gut shots to contend with....

I wouldn't buy a .22 centerfire for deer...But if you are a good enough shot and can pick and choose your angle then yes the .22 centerfires have enough energy to cleanly kill a deer...