We hunt in October and depending on the weather the meat could be frozen. We usually don't even put the meat in coolers. I have a 18-19 hour drive (1200 miles) and the meat is still cold when we get home. Keep it out of the sun and it will be fine. I have seen a lot of people use freezers (some even run a generator while driving) and I have seen the box with tyvek type insulation in it also. You shouldn't need to lift the coolers/freezer. Put it in the back of the truck and carry the meat to it rather than trying to lift all the weight at once. The key is to get the meat frozen or cold before you leave. Hang it overnight or bury it in the snow. If there is snow on the ground fill the cooler with that. Getting the meat wet isn't a problem, I just don't like to let it soak so we drain it and add more ice if needed (when you hit warm weather).