RE: what size gun should wife use?
size has nothing to with it. I am little and can handle more recoil than guys twice my size. I used to have a 30-06 when I weighed 90 lbs. I'm not going to say it didn't throw me around, but I shot it just fine.
I think the .243 is a great caliber though. I also think if she shot enough a .270 in the right rifle with a good recoil pad would make a nice all around gun for her. Just remember light guns kick more. And you really don't notice in the field.
Paul