RE: Better yote round
I'm sure there really isn't any major differences between the 2 calibers that you mentioned, at least not if you aren't shooting over 300 yards. Then the 22-250 shines. If it was me and it was a dedicated 'yote gun I'd opt for a 243....Wait, thats just me, I used to always use a 223, but it seems like the wind is always blowing good when i'm out and I wanted something to buck the wind a lil bit better.
The 223 will stone 'em out to 425 yards, I've done it.