By Cayugad::::No. Both rifles are as accurate as you make them.
I agree; you can make a 45 and a 50 cal. shoot the same if you work it up and know how they shoot.
I shoot a 45 cal. with 225gr. powerbelts , 100 gr. pyrodex. out to 145 to 150 yards,I will put it up with any 50 ca.