The 270 hands down for a 250 yard shot it would be hard to beat.

I still have my first deer gun. It is a Savage mod. 110, 270. It loves the hell out of the Horn. 130 light mags. I've got a old Redfield Golden 5 Star on it and I really dont think it will ever miss a Deer. I might be a little Pred.
but I still dont think it will.

hunter338