Hi partsjay, Your question is a good one.Deciphering deer runs can be a big piece of creating a successful strategy.What you want to try to establish is how the runs correlate to bedding and feeding area's.If you don't know that about the run you are familiar with you would probably want to walk the run out in both directions to determine where the deer are bedding and feeding.A big consideration is to realize that the well worn deer runs that you see are being used by family groups of does and their off spring,with perhaps some 11/2 year old bucks in the mix.These runs can be productive if animals of that nature are what you are targeting.
There are to many seasonal variables to address here as it relates to where to set up to kill a mature buck,if you wish to dig deeper in to that feel free to PM me.
Good luck to you,I hope you have a lot of fun!