A lot depends on what you need,I hunt an area where there are open medows for elk,since the 250 bonded have come out its just a matter of weather to use a bonded 250[I tried them on wild boar and the penatration immpressed me] or the 50/40 -200gr; when all the personal preferances are aside they will all do the job its bullet placement that is important so I shoot what groups best at long range under weather and terran conditions as close to hunting conditions as possible. Lee