45s are easier to shoot well in heavy all steel guns, like a 1911.
I know in IL, semi autos are not legal for deer, but I think you can use anything for yotes. The deer caliber requirement for deer in IL is at least 30 cal, and 500 foot pounds of energy at the muzzle. I guess you could use a hot 45 round in a 45 revolver made to take moon clips.

I don't think I would want to use a 45 on deer anyway, as a first choice. They still sometimes run after getting whacked by a 44mag.