I collect guns but pretty much stay with the same few in the "stable" for my hunting. I started with an iron sighted 7 X 57, went to a scoped .243 in my late 20's as my glasses got thicker. I was given a custon '98 in 8mm/06 but so far have only played with it, not hunted much with it. I then played around with a few 6.5 X 55's, but mostly ended up carrying the .243
I finally bought myself a Savage package gun in 30/06 (always wanted the all american round - stolen and improved from the Germans basically!) and successfully used it when hunting specific larger animals (I usually am a meat hunter and prefer the younger, tastier ones anyway!)
Usually I go for the .243, but am currently trying to refine a particular 6.5 Swede to turn it into my go-to gun. It just needs some tweaking on the accuracy side and then a little fit-and-finish work.
I have many more guns and more calibers and rifles in the stable, but they are mostly for shooting at the range and playing around with.