I think it boils down to what you like and the way you use it.
Personally I used a 54 cal round ball and a 54 sabot with a widner 300 gr Soft Point 50 cal bullet shot them in the back edge of the shoulder past through both lungs and both were down in about 50 yd. I pick my shots and have never had a problem with deer elk or bear. I have often wondered why people feel the need for these super heavy bullets when a nice combination of weight,velocity and shot placement. I plan to try a 50 cal next time around. Lee