The 25-06 is a excellent round. I believe its to hot to take say to a prairie dog town, It will absolutely turn a coyote inside out. I love em. Though it does quite a bit of damage to the pelt, if that is a concern. with me its not. You can kill anything up to and including elk so long as you take reasonable shots. As to range, I would say that the gun will shoot farther than either you or I are capable of, so the limit will be your abilities.